Scientist, Disease Modeling and Phenotyping at Synapticure

About Synapticure As a patient and caregiver-founded company, Synapticure provides instant access to expert neurologists, cutting-edge treatments and trials, and wraparound care coordination and behavioral health support in all 50 states through a virtual care platform. Partnering with providers and health plans, including CMS' new GUIDE dementia care model, Synapticure is dedicated to transforming the lives of millions of individuals and their families living with neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS. The Role As part of building the next generation of neurodegenerative care, Synapticure is investing in cutting-edge biological platforms to understand and treat ALS, FTD, and related diseases at the cellular level. We are developing a novel patient-derived disease modeling platform using in vitro systems to advance our ability to screen, diagnose, and develop therapeutics tailored to patient-specific biology. Our initial focus is ALS and FTD, but our long-term vision includes applications across a wide spectrum of neurodegenerative disorders. We are seeking a Scientist, Disease Modeling and Phenotyping who thrives at the intersection of hands-on laboratory work and computational biology. In this full-time, in-person role based in Philadelphia, PA, you will lead the development of high-throughput iPSC-based cell models and apply phenotypic screening approaches using advanced imaging, transcriptomics, and biochemical assays. Your work will directly support the discovery and advancement of new diagnostics and therapeutics for patients living with neurodegenerative diseases. You’ll play a critical role in both the wet lab and analytical domains;developing screening protocols, executing experiments, and helping analyze and interpret complex datasets. This is a unique opportunity to contribute directly to the future of neurodegenerative disease research while collaborating with a cross-disciplinary team of biologists, neuroscientists, clinicians, engineers, and data scientists. If you're motivated by science with impact, this role offers the chance to make a real difference in patients’ lives. Job Duties – What you’ll be doing • Design and execute phenotypic screening protocols for complex, cell-based assays using high-content imaging and transcriptomic readouts. • Conduct hands-on wet lab work, including iPSC culture, differentiation, assay development, and imaging. • Analyze and interpret multi-dimensional datasets including image-based screens and RNA-seq data. • Collaborate cross-functionally to ensure data quality, reproducibility, and relevance to patient biology. • Troubleshoot experimental workflows, including cell-line scale-up, instrument scheduling, and protocol optimization. • Lead cellular screens at scale and contribute to the selection and onboarding of new technologies and methodologies. • Ensure laboratory SOPs are followed and participate in lab operations, including inventory and process standardization.Maintain awareness of cutting edge disease-relevant and stem-cell modeling publications Requirements – What we look for in you • PhD (or equivalent experience) in neuroscience, biomedical sciences, bioengineering, computational biology, or a related discipline. • Strong experience with wet lab techniques, particularly iPSC culture, differentiation, imaging, qPCR, and protein assays. • Interest or experience in basic computational biology or high-content data analysis. • Excellent documentation, scientific communication, and project management skills. • Ability to collaborate in a multidisciplinary environment and juggle multiple projects at once. • Adaptability in a dynamic startup setting with a proactive, solution-oriented mindset. Preferred Qualifications • Experience with transcriptomic or omics analysis (RNA-seq, single-cell). • Proficiency in microscopy techniques, including immunohistochemistry, 3D imaging, and high-content imaging. • Experience in neurodegenerative disease modeling. • Familiarity with both 2D and 3D cell culture systems. • Knowledge of automation, liquid handling, and/or high-throughput screening platforms. We’re founded by a patient and caregiver. This means our values are at the heart of everything we do, and while we’re located all across the country, these principles are what tie us together around a common identity: • Relentless focus on patients and caregivers. We are determined to provide an exceptional experience for every patient we have the privilege to serve, and we put our patients first in everything we do. • Embody the spirit and humanity of those living with neurodegenerative disease. Inspired by our founders, families and personal experiences, we recognize the seriousness of our patients’ circumstances, and meet that challenge every day with empathy, compassion, kindness, joy, and most importantly – with hope. • Seek to understand, and stay curious. We start by listening to one another, our partners, our patients and their caregivers. We communicate with authenticity and humility, prioritizing honesty and directness while recognizing we always have something to learn. • Embrace the opportunity. We are energized by the importance of our mission, and bias toward action. Work Location: This position is in-person and based in our Philadelphia, PA laboratory.