People Operations Manager at Billiontoone

Ready to redefine what's possible in molecular diagnostics? Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today. Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong. BillionToOne is looking for a People Operations Manager to join our growing People team and play a critical role in scaling our people programs, systems, and operations. This role will own and enhance core People Ops programs while serving as a key partner in driving operational excellence, vendor strategy, and data-informed decision-making. The ideal candidate brings deep expertise in benefits, strong program and project management skills, and a data-driven mindset, with the ability to anticipate needs and proactively improve processes in a fast-paced, high-growth environment. This is a hybrid role (2–3 days onsite per week at our Menlo Park and/or Union City office) reporting to the Associate Director of People Operations. Responsibilities: • Design, optimize, and scale core People Ops programs (onboarding, offboarding, performance cycles, engagement/recognition, and compliance), driving strategy, scalability, and continuous improvement • Own and scale benefits strategy and operations, serving as the primary lead for vendor partnerships (benefits brokers, payroll providers, etc.) • Act as the program manager for performance cycles, driving end-to-end execution, stakeholder alignment, and continuous improvement • Design and implement scalable processes and systems, proactively identifying gaps and driving operational efficiency • Partner with the Associate Director to operationalize strategic initiatives (e.g., recognition program, engagement survey, etc.) • Maintain strong policy and compliance knowledge, recommending updates to enhance both compliance and employee experience • Serve as the Tier 2 escalation point for complex employee inquiries, resolving issues independently and escalating only critical matters as needed Qualifications: • 5+ years of experience in People Operations, HR Generalist, or similar roles, preferably in a high-growth or startup environment • Strong expertise in benefits administration and vendor management • Proven experience leading cross-functional programs or cycles (e.g., performance management, compensation, or engagement programs) • Demonstrated ability to design and improve scalable processes and systems • Strong analytical skills with experience using data to drive decisions • Excellent project management, organizational, and prioritization skills • Strong communication skills with the ability to influence and partner across levels • High attention to detail, sound judgment, and a proactive mindset • “Scrappy,” solutions-oriented approach with a focus on continuous improvement • Previous experience in start-up is highly desired Benefits And Perks: • Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients • Open, transparent culture that includes weekly Town Hall meetings • The ability to indirectly or directly change the lives of hundreds of thousands patients • Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80% • Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%) • Supplemental fertility benefits coverage • Retirement savings program including a 4% Company match • Increase paid time off with increased tenure • Latest and greatest hardware (laptop, lab equipment, facilities) • Daily on-site lunches provided from top eateries • A variety of perks on campus (state of the art gym, restaurant) • Free on-site EV charging (compatible with all EVs, including Tesla) At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.). For this position, we offer a total compensation package of $259,893 per year, including a base pay range of $139,340 - $160,777 per year. BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. For more information about how we protect your information, we encourage you to review our Privacy Policy. BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide. Our Impact Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care. Our Growth From $0 to $150M+ in Annual Recurring Revenue in just five years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. Our Recognition Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees. Our Future Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started. Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com