Associate Director, FP&A at Crescent Biopharma

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit www.crescentbiopharma.com and follow the Company on LinkedIn and X.   We are seeking an Associate Director of FP&A to support corporate and program level planning, budgeting, and forecasting. This individual will partner closely with R&D, Program Management, Clinical, Tech Ops, and G&A teams to deliver high quality financial insights, support decision making, and ensure disciplined financial management in a dynamic, science-driven environment.     This role is ideal for someone who thrives in high growth biotech, can balance strategic thinking with hands on execution, and is excited to build scalable FP&A processes.  Please note, this person must be local to the Waltham, MA office and have experience in the life sciences, biotech FP&A-space. Responsibilities • Own the FP&A function across the full early-stage oncology portfolio, spanning discovery research, preclinical development, IND-enabling programs, and Phase I/II clinical trials • Serve as a strategic finance partner to the Chief Scientific Officer, Head of Clinical Development, and SVP of Tech Ops, providing financial insight and decision support tied to asset progression and portfolio prioritization • Lead program-level and portfolio-level financial modeling, including cost-to-complete analyses, risk-adjusted NPV assessments, and scenario planning around key preclinical and early clinical inflection points such as IND filings, RP2D determinations, and preliminary efficacy signals • Oversee financial management of CDMO and CRO relationships supporting IND-enabling toxicology, drug substance/drug product manufacturing scale-up, and Phase I/II clinical execution, including governance of budgets, change orders, and milestone payment schedules • Drive the annual operating budget, mid-year reforecast and multi-year long-range plan, working cross-functionally with research, CMC, translational medicine, regulatory, and clinical teams to align financial projections with program timelines and go/no-go criteria • Develop and maintain capital runway models and cash burn analyses to support treasury planning, board reporting, and investor communications at a stage where capital efficiency is critical • Build and refine FP&A infrastructure including forecasting tools, program tracking systems, and reporting cadences suited to the pace and uncertainty of early-stage drug development • Present financial results, program spend analyses, and strategic scenarios to the leadership team • Partner with accounting colleagues to build financial discipline and cross-functional partnership skills appropriate for a fast-moving early-stage biotech environment • Support business development activities including in-licensing diligence, sponsored research agreement structuring, and collaboration deal modeling focused on early-stage oncology assets Education & Experience • Bachelor’s degree in Finance, Accounting, Economics, or related field. • 8+ years of progressive FP&A experience within biotech or pharma space • Experience supporting R&D, clinical development, or other multiprogram environments • Experience with biotech planning cycles (e.g., program budgeting, CRO/CMO forecasting) preferred • Familiarity with ERP systems, planning tools, and business intelligence platforms (e.g., NetSuite, Adaptive Insights a plus) • Demonstrated ability to partner cross-functionally and communicate complex concepts clearly • Ability to manage competing priorities and operate in a fast-paced, high-growth environment • Highly analytical with strong attention to detail • Proactive problem solver who anticipates needs • Strong interpersonal skills and business judgment • Collaborative team player What We Offer • Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment • Competitive compensation, including base salary, performance bonus, and equity • 100% employer-paid benefits package • Flexible PTO; also, two, one-week company-wide shutdowns each year • A commitment to your professional development, with access to resources, mentorship, and growth opportunities Salary range The salary range for this position is $180,000 to $210,000. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. Additional Description for Pay Transparency: The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation – Unlimited PTO; Sick time – 10 days per calendar year; Holiday pay, including two Company shut downs; Parental Leave – 16 weeks within one year of the birth/adoption/foster care of a child; FMLA; Military Leave. Additional information can be found - [Upgrade to PRO to see link] Please note: Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.  Please note, Crescent does not accept unsolicited resumes from external agencies or recruiters. Submission of a resume without a prior written agreement does not create any express or implied contract between Crescent and the agency. Crescent will not pay any fees related to unsolicited resumes. #LI-CBIO