Director, Head of Product Management – AI-Enabled Precision Medicine (Therapeutics & Innovations) at Natera

Director, Head of Product Management – AI-Enabled Precision Medicine (Therapeutics & Innovations) About Us We are redefining the future of precision medicine by integrating AI with healthcare to create next-generation, precision treatment modalities. Our multidisciplinary team is building products at the intersection of clinical data, multi-omics, and machine learning—unlocking entirely new approaches to drug development and patient care. Within the Therapeutics & Innovations Business Unit, we are developing a new category that bridges diagnostics and therapeutics. Our platform combines deep scientific expertise with proprietary datasets to power AI-enabled solutions that can transform how therapies are discovered, developed, and deployed. We are looking for a product leader who can translate this potential into real, scalable products—owning the strategy, roadmap, and execution to bring these innovations to market. The Role We are seeking a Director / Head of Product Management to lead product strategy and execution for our AI-enabled therapeutics platform. This is a highly cross-functional leadership role at the center of science, engineering, clinical development, and commercial strategy. You will define what we build, why it matters, and how it creates value—for biopharma partners, clinicians, and ultimately patients. You will own the product lifecycle end-to-end: from concept and validation through development, launch, and iteration. This role requires a rare blend of scientific fluency, product rigor, and commercial instinct. You will work closely with R&D, AI, medical, business development, and marketing to ensure our products are scientifically credible, operationally feasible, and commercially compelling. What You’ll Do Product Strategy & Vision • Define and own the product vision and roadmap for AI-enabled tools for precision medicine offerings (e.g., biomarkers, trial enablement tools, co-development platforms) via genomic language models, biomedical AI agents, AI-driven analysis platforms, forecasting algorithms. • Identify high-value use cases across drug development (e.g., trial design, patient selection, translational insights, companion diagnostics). • Translate platform capabilities into clear product strategies aligned with business goals. Product Development & Execution • Lead the end-to-end product lifecycle: concept → validation → build → launch → iteration. • Partner with R&D, data science, and engineering to define product requirements and ensure high-quality execution. • Drive prioritization decisions across competing opportunities based on impact, feasibility, and strategic alignment. Customer & Market Insight • Engage with biopharma partners, clinicians, and internal stakeholders to deeply understand needs and workflows. • Synthesize customer insights into product requirements and roadmap decisions. • Continuously assess market trends, competitive landscape, and emerging technologies. Cross-Functional Leadership • Serve as the central hub across Product, R&D, Clinical, BD, and Marketing. • Align stakeholders around a unified product strategy and execution plan. • Drive decision-making in a matrixed, fast-moving environment. Commercialization & Launch • Partner with commercial and BD teams to define product positioning, packaging, and pricing. • Support go-to-market strategy, including pilot programs, partnerships, and scaled deployments. • Ensure successful product launches with clear value propositions and supporting evidence. Data, Evidence & Validation • Define requirements for product validation, including analytical, clinical, and real-world evidence. • Ensure products meet scientific, regulatory, and commercial expectations. • Partner with clinical and regulatory teams to align product strategy with approval pathways where applicable. Team Building & Leadership • Build and mentor a high-performing product management function. • Establish product processes, operating cadence, and best practices. • Foster a culture of ownership, speed, and scientific rigor. What We’re Looking For • Advanced degree (PhD, MD, MS, or equivalent) in life sciences, bioengineering, computational biology, or related field preferred. • 8–12+ years of experience in product management, product strategy, or related roles in biotech, life sciences, or healthcare technology. • Proven track record of building and launching complex, data-driven products. • Strong understanding of drug development workflows and/or clinical diagnostics. • Experience working with AI/ML-driven products or data platforms is highly preferred. • Exceptional ability to translate complex science into clear product decisions and strategies. • Demonstrated success leading cross-functional teams in ambiguous environments. • Strong commercial acumen, including product-market fit, pricing, and partnership models. Bonus: • Experience with biomarker development, oncology, or precision medicine. • Background in diagnostics + therapeutics integration. • Experience in early-stage or high-growth environments. Why Join Us • Build and define an entirely new category at the intersection of AI, diagnostics, and therapeutics. • Own product strategy for some of the most advanced datasets and capabilities in healthcare. • Work alongside world-class scientists, clinicians, and business leaders. • Directly impact how therapies are developed and delivered to patients. The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.Remote USA$184,600—$230,700 USD Compensation & Total Rewards This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations. This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including: • Annual performance incentive bonus • Long-term equity awards • Comprehensive health benefits (medical, dental, vision) • 401(k) with company match • Generous paid time off and company holidays • Additional wellness and work-life benefits Compensation Range $184,600—$230,700 USDOUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit www.natera.com. Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Link: [Upgrade to PRO to see link] Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. For more information: - BBB announcement on job scams - FBI Cyber Crime resource page